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With the literature, we discovered that the antimicrobial motion of benzofuran derivatives appears to become quite a bit more depending on substitution within the heterocyclic furan ring than on substitution in the aromatic moiety.

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Benzofuran is definitely the heterocyclic compound consisting of fused benzene and furan rings. This colourless liquid will likely be a ingredient of coal tar.

proceeded by nucleophilic substitution with phenol 119 to create intermediate B by the use of an interrupted Pummerer

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utilization of cuprous bromide) to make intermediate C. The intermediate C then afforded benzofuran derivatives 19 by the use of intramolecular nucleophilic assault and isomerization

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